CPE Faculty and Staff
Michael S. Detamore
Assistant
Professor of Chemical and Petroleum Engineering
Courtesy Assistant Professor of Mechanical Engineering
B.S. Chemical Engineering, University of Colorado at Boulder, 2000
Ph.D., Bioengineering, Rice University, 2004
Room: 4132 B Learned Hall
Office Phone: (785) 864-4943
Lab Phone: (785) 864-1824
Fax: (785) 864-4967
E-mail: detamore@ku.edu
Visit Dr. Detamore's Lab Website
Publication List
Conference Presentations
Courses
Research Interests
The
temporomandibular joint (TMJ), which is the jaw joint, is the central theme of
our research. We are interested in understanding the biomechanical behavior of
the TMJ, from the standpoints of both tissue biomechanics and joint motion
biomechanics. However, tissue engineering is the primary objective of our
group, and the focus of our tissue engineering efforts is the condyle of the
mandible.
Tissue Engineering
We
are interested in examining the effects of chemical signals, including chondrogenic
agents and osteogenic agents, on cells from the mandibular condyle.
Furthermore, we are interested in understanding how these different cell types
influence each other at the osteochondral interface in engineered constructs. Tissue engineering efforts are also focused on scaffold selection, comparing
natural and synthetic polymers, and on development of a direct-perfusion
bioreactor for larger-scale constructs, where passive diffusion of nutrients
and waste products becomes a limiting factor.
TMJ Biomechanics
Our focus is to elucidate the anisotropic and viscoelastic nature of condylar cartilage under tension and compression.
This work will provide a tool for us to help find a place for this cartilage in
the cartilage spectrum, which spans from the elastic cartilages of the ear and
nose to the fibrocartilaginous TMJ disc and knee meniscus to hyaline cartilage
of the knee and hip. Biomechanical testing of condylar cartilage will be
performed under both compression and tension. In addition, we are interested
in the compressive behavior of the condyle bone tissue.
Snider GR, Lomakin J, Singh M, Gehrke SH, DETAMORE MS, "Regional dynamic tensile properties of the TMJ disc", Journal of Dental Researchi, Accepted, 2008
Wang L, Lazebnik M, DETAMORE MS, "Hyaline cartilage cells outperform mandibular condylar cartilage cells in a TMJ fibrocartilage tissue engineering application", Osteoarthritis and Cartilage, Accepted, 2008
Wang L, Seshareddy K, Weiss ML, DETAMORE MS, "The effect of initial seeding density on human umbilical cord matrix mesenchymal stromal cells for fibrocartilage tissue engineering", Tissue Engineering Part A, Accepted, 2008
Singh M, Berkland CJ, DETAMORE MS, "Strategies and applications for incorporating signal and biomaterial gradients in tissue engineering", Tissue Engineering Part B: Reviews, Accepted 2008
Singh M, Morris CP, Ellis R, DETAMORE MS, Berkland CJ, "Microsphere-based seamless gradient scaffolds for tissue engineering", Tissue Engineering Part C: Methods, Accepted 2008
Wang L and DETAMORE MS, "Effects of growth factors and glucosamine on porcine mandibular condylar cartilage cells and hyaline cartilage cells for tissue engineering applications",Archives of Oral Biology, Accepted, 2008
Singh M and DETAMORE MS, "Tensile properties of the mandibular condylar cartilage",Journal of Biomechanical Engineering, 130 (1): 011009-1 . 011009-7, 2008
Tanaka E, DETAMORE MS, Mercuri LG, "Degerative disorders of the temporomandibular joint: Etiology, diagnosis, and treatment," Journal of Dental Research, 87(4): 296-307, 2008
Tanaka E, DETAMORE MS, Tanimoto K, Kawai N, "Lubrication of the temporomandibular joint", Annals of Biomedical Engineering, 36 (1): 14-29, 2008
Wang Q, Wang L, DETAMORE MS, Berkland C, "Biodegradable colloidal gels as moldable tissue engineering scaffolds", Advanced Materials , 20 (2): 236-239, 2008
Wang L and DETAMORE MS, "Tissue engineering the mandibular condyle", Tissue Engineering , 13 (8): 1955-1971, 2007 (Special Issue on .Emerging Technologies and New Basic Science Directions in Tissue Engineering.)
Bailey MM, Wang L, Bode CJ, Mitchell KE, DETAMORE MS, "A comparison of human umbilical cord matrix stem cells and TMJ condylar chondrocytes for tissue engineering TMJ condylar cartilage", Tissue Engineering, 13 (8): 2003-2010, 2007 (Special Issue on .Emerging Technologies and New Basic Science Directions in Tissue Engineering.)
DETAMORE MS, Mao JJ, Athanasiou KA, "A call to action for bioengineers and dental professionals: directives for the future of TMJ bioengineering", Annals of Biomedical Engineering, 35 (8): 1301-1311, 2007
Selected Pre-KU-Articles
DETAMORE MS, Athanasiou KA, "Use of a rotating bioreactor toward tissue engineering
the temporomandibular joint disc", Tissue Engineering, 11(7-8): 1188-1197, 2005
DETAMORE MS, Athanasiou KA, "Evaluation of three growth factors for TMJ disc tissue engineering",
Annals of Biomedical Engineering, 33 (3): 383-390, 2005
DETAMORE MS, Orfanos JG,
Almarza AJ, French MM, Wong ME, Athanasiou KA, "Quantitative analysis and
comparative regional investigation of the extracellular matrix of the porcine
temporomandibular joint disc", Matrix Biology, 24 (1): 45-57, 2005
DETAMORE MS and Athanasiou KA, "Motivation, characterization and strategy for tissue engineering the temporomandibular joint disc", Tissue Engineering, 9 (6): 1065-1087, 2003
DETAMORE MS and Athanasiou KA, "Structure and function of the temporomandibular joint disc: Implications for tissue engineering", Journal of Oral and Maxillofacial Surgery, 61 (4): 494-506, 2003
DETAMORE MS and Athanasiou
KA, "Tensile properties of the porcine temporomandibular joint disc", Journal
of Biomechanical Engineering, 125 (4): 558-565, 2003
Educational article
DETAMORE MS, Schmedlen RH, "Teaching
a graduate-level course in tissue engineering", Chemical Engineering Education,
39(4): 272-278, 2005
Wang L, DETAMORE MS, "The effects of insulin-like growth factor and transforming growth factor-beta on human umbilical cord stromal cells", Biomedical Engineering Society, St. Louis, MO (October, 2008)
Wang L, DETAMORE MS, "Human umbilical cord mesenchymal stromal cells for bone tissue engineering: differentiation and optimal seeding densities", Biomedical Engineering Society, St. Louis, MO (October, 2008)
Wang L, Tran I, Seshareddy K, Weiss ML, DETAMORE MS, "A comparative study between human umbilical cord and bone marrow stromal cells for cartilage tissue engineering", Biomedical Engineering Society, St. Louis, MO (October, 2008)
Singh M, Christian J, Salash J, Berkland C, DETAMORE MS, "PLGA microsphere-based stiffness-gradient scaffolds for osteochondral tissue engineering", Biomedical Engineering Society, St. Louis, MO (October, 2008)
Singh M, Sandhu B, Scurto A, Berkland C, DETAMORE MS, "Subcritical CO2-melded microsphere-based scaffolds for cartilage tissue engineering", Biomedical Engineering Society, St. Louis, MO (October, 2008)
Lazebnik M, Singh M, Zhao L, Berkland C, DETAMORE MS, "Novel hybrid scaffolds for the intervertebral disc tissue engineering", Biomedical Engineering SocietySt. Louis, MO (October, 2008)
Zhao L, DETAMORE MS, "Chondrogenic differentiation of human umbilical cord mesenchymal stromal cells", Biomedical Engineering Society, St. Louis, MO (October, 2008)
Wemer RD, DETAMORE MS, Weatherly RA, "Immunohistochemical characterization of the rabbit trachea", American Broncho-Esophogological Association, Combined Otolaryngology Spring MeetingOrlando, FL (May, 2008)
Roatch CH, Gehrke SH, DETAMORE MS, "Biocompatible dual network gels for cartilage regeneration", Society for Physical Regulation in Biology and Medicine, Miami, FL (January, 2008)
DETAMORE MS, Singh M, Christian J, Salash J, Berkland C, "Gradient-based scaffolds for osteochondral regeneration", Society for Physical Regulation in Biology and Medicine, Miami, FL (January, 2008)
Singh M, Morris CP, Ellis R, DETAMORE MS, Berkland C, "Microsphere-based seamless gradient scaffolds for tissue regeneration", Orthopaedic Research Society . 6th combined meeting, Honolulu, HI (October, 2007)
Singh M, DETAMORE MS, "Viscoelastic characterization of the mandibular condylar cartilage under unconfined compression", Orthopaedic Research Society . 6th combined meeting, Honolulu, HI (October, 2007)
Snider GR, Singh M, Lomakin J, Gehrke SH, DETAMORE MS, "Regional and directional dynamic tensile properties of the temporomandibular joint disc", Biomedical Engineering Society, Los Angeles, CA (September, 2007)
Wang L and DETAMORE MS, "Comparing glucosamine and insulin-like growth factor effects on mandibular condylar cartilage cells", Biomedical Engineering Society, Los Angeles, CA (September, 2007)
Wang L, Seshareddy K, Weiss ML, DETAMORE MS, "Effects of seeding density on umbilical cord matrix stem cells for fibrocartilage tissue engineering", Biomedical Engineering Society, Los Angeles, CA (September, 2007)
Professional Affiliations:
American Society of TMJ Surgeons (2006 - Present)
Fellow of the Midwest Institute for Comparative Stem Cell Biology (2006 - Present)
Biomedical Engineering Society (2001 - Present)
American Institute of Chemical Engineers (1997 - Present)
American Society for Engineering Education (2004 - Present)
Society for Physical Regulation in Biology and Medicine (2006 - Present)
CPE 211 Material and Energy Balances
CPE 511 Momentum Transfer
CPE 656/756 Introduction to Biomedical Engineering
CPE 715 Tissue Engineering
Continuum Biomechanics, co-instructor Spring 2004 @ Rice University
Honors and Awards:
Best Thesis in Physical Sciences and Mathematics, Sigma Xi Rice University/Texas Medical Center Chapter
(Rice University, M.D. Anderson Cancer Center, University of Texas Health Science Center, Baylor College of Medicine),
April 2004- April 2005
Nettie S. Autrey Fellowship, Top Graduate Student in Engineering and Science at Rice University, 2003/2004
Gould Award for Distinguished Service in Undergraduate Engineering Advising (2008)
Miller Award for Distinguished Service to the Engineering Profession, KU Engineering (2006)
Chair, TMJ Bioengineering Conference (May 2006)
